一、个人简介

郝志强，男，博士，商洛学院生物医药与食品工程学院讲师。主要研究方向为生物信息学和功能基因组学，参与发表多篇SCI研究论文，参与国家自然科学基金项目一项。在教学方面主要从事本科生《酶工程》《基因工程实验》、《酶工程实验》等课程的教学工作。

 

二、研究领域

1. lncRNA等非编码RNA的识别及功能研究。主要在动植中利用生物信息学手段进行lncRNAs识别工具开发，利用生物网络  等多种方法分析非编码RNA潜在功能。

2. 地下鼠对地下低氧环境适应的研究。利用高通量组学数据挖掘地下鼠低氧适应关键基因、生物过程、通路等。

 

三、参与发表的科研论文

[1] Hao Z, Xu L, Zhao L, He J, Li G, Li J. (2021). Transcriptome analysis of the liver of Eospalax fontanierii under hypoxia. PeerJ 9:e11166.

[2] Hao Z, Ming F, Guo J, Li G, He J, Jin G. (2021).Identification and functional analysis of lncRNAs responsive to hypoxia in Eospalax fontanierii. Curr. Issues Mol. BIol.

[3] Hao Z, Fan C, Cheng T,  Su Y, Wei Q, Li G, et al. (2015). Genome-wide identification, characterization and evolutionary analysis of long intergenic noncoding rnas in cucumber. Plos One, 10(3), e0121800.

[4] Tang B^#, Hao Z^#, Zhu Y, Zhang H, Li G. (2018). Genome-wide identification and functional analysis of circrnas in zea mays. PLoS ONE, 13(12).

[5] Xu L^#, Hao Z^#, Lin J, Zhao Q, Li J. (2019). Transcriptome sequencing of Epospalax fontanierii to determine hypoxia regulation of cardiac fibrinogen. Molecular Biology Reports, 46(27).

[6] Zhang J^#, Hao Z^#, Yin S, Li G. (2020). Greencircrna: a database for plant CircRNAs that act as miRNA decoys. Database.

[7] Fan C, Hao Z, Yan J, Li G. (2015). Genome-wide identification and functional analysis of lincRNAs acting as miRNA targets or decoys in maize. BMC Genomics, 16(1), 793.

[8] Lin J, Fan L, Y Han, Guo J, Hao Z, Li J. (2021). The mtorc1/eif4e/hif-1α pathway mediates glycolysis to support brain hypoxia resistance in the Gansu Zokor, Eospalax cansus. Frontiers in Physiology, 12, 626240.

[9] Lin J, Yang Q, Guo J, Li M, Hao Z, He J and Li J. (2022) Gut Microbiome Alterations and Hepatic Metabolic Flexibility in the Gansu Zokor, Eospalax cansus: Adaptation to Hypoxic Niches. Front. Cardiovasc. Med. 9:814076.

[10] 樊春燕, 魏强, 郝志强, 李广林. (2014). miRNAs调控lincRNAs的生物信息学预测与功能分析. 遗传, 36(12), 1226-1226.

[11] Zhao Y, Hu T, Liu R, Hao Z, Li G. (2021). Biochemical characterization and function of eight microbial type terpene synthases from lycophyte Selaginella moellendorffii. International Journal of Molecular Sciences, 22(2), 605.

[12] Li G, Hao Z, Fan C, Wu X. (2017). Genome-Wide Function Analysis of lincRNAs as miRNA Targets or Decoys in Plant. Plant Epigenetics. Springer, Cham, Pages 149-162. https://doi.org/10.1007/978-3-319-55520-1_8 

[13] Hao Z, Li, G. (2021). Chapter 12 - Genome-wide identification and functional analysis of lincRNAs in cucumber. Long Noncoding RNAs in Plants,Academic Press, Pages 189-196. https://doi.org/10.1016 /B978-0-12-821452-7.00012-X

四、联系方式

通讯地址：陕西省商州区北新街10号商洛学院生物医药与食品工程学院，726000

邮箱：haozhiqiang@snnu.edu.cn